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Andrographolide CAS 5508-58-7

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Andrographolide CAS 5508-58-7

Andrographolide is a diterpenoid lactone compound extracted from andrographolide leaves. 

Category:

Description

The appearance of andrographolide is white square prism or flake crystal, with melting point of 224-230℃ (decomposition), which is soluble in boiling ethanol, slightly soluble in methanol or ethanol, very slightly soluble in chloroform, and insoluble in water or ether.  Andrographolide has no odor and a very bitter taste. Andrographolide has the effect of heat and detoxification removing, anti-inflammatory and analgesic, and has special effect on bacterial and viral infection at upper respiratory tract and dysentery, so it is known as natural antibiotics. 

Chemical property:

Product nameAndrographolide; Kariyt extract
CAS NO.5508-58-7
Molecular formulaC20H30O5
Molecular weight350.45
EINECS NO.226-852-5
Melting point229-232°C(lit.)
Specific rotation-126º(c=1.5,HAc)
Boiling point557.3±50.0°C
Density4211.2317
Storage+2C to +8C
Coefficient of acidity(pKa)12.36±0.2
AppearanceOff-white crystalline
Optical activity[α]20/D126°, c=1.5 inaceticacid
Maximum wavelength (λ Max)223nm(MeOH)(lit.)

Application:

Andrographolide or dehydroandrographolide and its derivatives, such as andrographolide tablets, andrographolide injection, yanhuning injection, have been widely used in clinical practice. 

Andropanolide is used for antibacterial, anti-inflammatory, heat-clearing, antipoison, which can not only be applied to the treatment of bacterial dysentery, acute gastroenteritis, mumps, tonsillitis, laryngitis and other diseases, but also can be used in the treatment of upper respiratory tract infection, HIV and other diseases.

Classification:

By purity
25% Andrographolide50% Andrographolide

Production:

1st processing2nd processing3rd processing

Kariyt leaf,

soak in 95% alcohol,

decoloration with activated carbon,

alcohol distillation and collection,

coarse crystalline

heat and dissolve in 15 times of 95% alcohol,

decoloration with activated carbon,

filter,

re-crystallization,

light yellow crystalline

distillation with water,

chloroform,

wash out with alcohol,

Andrographolide crystalline.

Test Report:

COA for 50 % Andrographolide

ITEMSTANDARDRESULT
Andrographolide    50 %50.37%
Physical&Chemical Property
AppearanceWhite PowderComplies
IdentificationPositiveComplies
Partical Size≥95% pass 80 meshComplies
Loss On Drying≤10.0%4.18%
Heavy Metals
Pb≤3.0mg/kgComplies
As≤2.0mg/kgComplies
Cd≤1.0mg/kgComplies
Hg≤0.1mg/kgComplies
Microbiological
Total Plate Count≤1,000cfu/gComplies
Yeast&Mold≤100cfu/gComplies
E.Coli or living miteNegativeComplies
ConclusionThe specifications conform with enterprise standards.

COA for 98 % Andrographolide

Certificate of Analysis
Product NameAndrographolide
Batch Number210803Package25kg/drum
Sample DateAug. 3rd, 2021Report DateAug. 4, 2021
Standard of Inspection: Internal Quality Control Standard (Comply with CHP)
ItemsStandardResults
AppearanceWhite Powder ,Odorless , bitter in tasteConforms
Other LactoneStain of sample solution is lighter than that of referenceConforms
Assay95% ~ 101.0%98.4%
Loss  on  Drying≤  1.0%0.5%
Residue  on  ignition≤  0.1%0.05%
Total  Plate  Count≤  1000CFU/gConfirms
Molds  and  Yeasts≤  100CFU/gConfirms
E.  ColiNegativeNot detected
ConclusionThe specifications conform with enterprise standards.
     

Packaging

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