Andrographolide CAS No. 5508-58-7

Description

The appearance of andrographolide is white square prism or flake crystal, with melting point of 224-230℃ (decomposition), which is soluble in boiling ethanol, slightly soluble in methanol or ethanol, very slightly soluble in chloroform, and insoluble in water or ether. Andrographolide has no odor and a very bitter taste. Andrographolide has the effect of heat and detoxification removing, anti-inflammatory and analgesic, and has special effect on bacterial and viral infection at upper respiratory tract and dysentery, so it is known as natural antibiotics.

Chemical property:

Product name	Andrographolide; Kariyt extract
CAS NO.	5508-58-7
Molecular formula	C20H30O5
Molecular weight	350.45
EINECS NO.	226-852-5
Melting point	229-232°C(lit.)
Specific rotation	-126º(c=1.5,HAc)
Boiling point	557.3±50.0°C
Density	4211.2317
Storage	+2C to +8C
Coefficient of acidity(pKa)	12.36±0.2
Appearance	Off-white crystalline
Optical activity	[α]20/D126°, c=1.5 inaceticacid
Maximum wavelength (λ Max)	223nm(MeOH)(lit.)

Application:

Andrographolide or dehydroandrographolide and its derivatives, such as andrographolide tablets, andrographolide injection, yanhuning injection, have been widely used in clinical practice.

Andropanolide is used for antibacterial, anti-inflammatory, heat-clearing, antipoison, which can not only be applied to the treatment of bacterial dysentery, acute gastroenteritis, mumps, tonsillitis, laryngitis and other diseases, but also can be used in the treatment of upper respiratory tract infection, HIV and other diseases.

Classification:

By purity
25% Andrographolide	50% Andrographolide

Production:

1st processing

2nd processing

3rd processing

Kariyt leaf,

soak in 95% alcohol,

decoloration with activated carbon,

alcohol distillation and collection,

coarse crystalline

heat and dissolve in 15 times of 95% alcohol,

decoloration with activated carbon,

filter,

re-crystallization,

light yellow crystalline

distillation with water,

chloroform,

wash out with alcohol,

Andrographolide crystalline.

Test Report:

COA for 50 % Andrographolide

ITEM	STANDARD	RESULT
Andrographolide	50 %	50.37%
Physical&Chemical Property
Appearance	White Powder	Complies
Identification	Positive	Complies
Partical Size	≥95% pass 80 mesh	Complies
Loss On Drying	≤10.0%	4.18%
Heavy Metals
Pb	≤3.0mg/kg	Complies
As	≤2.0mg/kg	Complies
Cd	≤1.0mg/kg	Complies
Hg	≤0.1mg/kg	Complies
Microbiological
Total Plate Count	≤1,000cfu/g	Complies
Yeast&Mold	≤100cfu/g	Complies
E.Coli or living mite	Negative	Complies
Conclusion	The specifications conform with enterprise standards.

COA for 98 % Andrographolide

Certificate of Analysis
Product Name	Andrographolide
Batch Number	210803	Package		25kg/drum
Sample Date	Aug. 3rd, 2021	Report Date		Aug. 4, 2021
Standard of Inspection: Internal Quality Control Standard (Comply with CHP)
Items	Standard		Results
Appearance	White Powder ,Odorless , bitter in taste		Conforms
Other Lactone	Stain of sample solution is lighter than that of reference		Conforms
Assay	95% ~ 101.0%		98.4%
Loss on Drying	≤ 1.0%		0.5%
Residue on ignition	≤ 0.1%		0.05%
Total Plate Count	≤ 1000CFU/g		Confirms
Molds and Yeasts	≤ 100CFU/g		Confirms
E. Coli	Negative		Not detected
Conclusion	The specifications conform with enterprise standards.